Mycobacterium tuberculosis is able to establish ...

Long-term bacterial infections represent some fundamental biological questions: how metabolically active bacteria in chronic infections? Do they share, or at rest? And how these bacteria evade the immune system so long? Acute infection by pathogenic bacteria caused rapid activation of innate and acquired immune response. If the agent remains the primary contact with the host immune system (and the host is not killed), the infection is usually cleared from the host adaptive immune system. However, some pathogenic bacteria infection support for the duration of their mammalian hosts, even in the presence of strong immune response. Most of what Weve learned about persistent infections comes from studies of a number of known diseases. For example,

Helicobacter Pylori, the cause of most stomach ulcers, lives in the stomach, where its persistence can be lifelong;

mycobacterium tuberculosis can establish long-term infections that can manifest as acute or chronic lung diseases versions, or be clinically asymptomatic yet retain potential for activation, and

Salmonella enterica,

specifically serotype Typhi, causes typhoid fever, systemic infection, which includes colonization of the reticuloendothelial network systemthe immune cells that reside in some connective tissue. Some infected people become lifelong carriers, periodically shedding large numbers of bacteria in the stool. They persistently infected carrier serves as a reservoir for pathogens and are essential for the survival of bacteria within a strattera price limited population of the owner. In humans, infection with another serotype Typhimurium, usually associated with self gastroenteritis and systemic disease is rare in most parts of the world. However, highly invasive species with nontyphoidal

Salmonella (NTS) has become a major public health problems in parts of Africa. Although the NTS strains are not usually stored in immunocompetent people is a serious concern about the potential that these strains can acquire this ability as they become more adapted individuals [

]. We are only now beginning to understand bacterial and host factors involved in hostpathogen interactions in chronic infections, and these new discoveries, is likely to provide new and interesting direction for research in microbial pathogenesis and immunology. .