In addition, mice with citrobacter rodentium-induced ...

Klebsiella pneumonia >> << are opportunistic pathogens and the normal component of the host flora. The aim of this project was to study the mechanisms that determine mucosal tissue colonization and infection of K. pneumonia. In this study, clinical respiratory isolate of Klebsiella pneumonia strain IA565, was as pathogenic in murine models of bacterial pneumonia and unable to colonize the lungs even in extreme conditions immunosuppressive. Strain IA565 brought intranasal and intragastric in immunocompetent and immunocompromised mice sterile mice and mice with intestinal inflammation. When strain IA565 was instilled intranasally and orally administered to wild-type mice, this voltage stable colonizing and stored in the nostrils and ZHKT. Interestingly, intranasal inoculation of wild type (WT), sterile (GF), and severely immunocompromised mice strain IA565 displayed similar levels of CFU in the nasal cavity. In contrast, strain IA565 gastrointestinal tract (GIT) CFU levels in mice GF significantly higher than in WT mice suggests that, in the presence of normal intestinal microflora, IA565 growth is controlled and maintained at low levels. In addition, mice with Citrobacter rodentium caused by inflammation of the intestine displayed no change in IA565 GI colonization compared with WT mice, and no change in disease outcome. However, DSS-mice treated with displayed significantly higher levels of IA565 gut CFU compared to the WT level shows that the host mediated inflammation may alter the microbial colonization. Together, these data

indicate that strain IA565 colonization of the nasal cavity can be achieved in immunocompetent, immunocompromised, and GF mice. Thus, nasal colonization is independent of host factors and indigenous microflora. This is in contrast to the IA565 GI colonization where host factors strattera 40mg mediating certain types of inflammation may alter the CFU levels and absence of intestinal microflora results in increased IA565 growth. This study is the first to identify and describe the mechanisms that influence the growth and behavior of murine kommensalnyh body. .